posted by Tess on Nov 21
The term ‘organic’ is contextual and has various meanings. For the purpose of this article organic means as much as it relates to bodily organs.
The two major organs involved in the development of Cushing’s syndrome in dogs are the two glandular organs of the endocrine system - the pituitary and the adrenal glands (to be particular, the adrenal cortex). The pituitary is the parent gland that releases Adrenocorticotropin hormone (ACTH) to signal the adrenal cortex to release the stress hormone, cortisol.
Excess of this hormone is the basic cause of Cushing’s syndrome. Excessive levels of cortisol may be caused due to a problem, usually a tumor, with the pituitary or the adrenal gland. When the problem is caused due to a pituitary tumor, it is known as Cushing’s disease.
Regardless of the nature of these tumors, benign or malignant, the result is increase in production of cortisol. Dogs that have previously undergone corticosteroid therapy for allergies or immune diseases are also at a risk of developing symptoms of Cushing’s syndrome.
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